| Player | Team | Action | Details | |
|---|---|---|---|---|
| Thairo Estrada | The Bluth Company | DROP | to FA | 12:07 am, 7/10/21 |
| Rowdy Tellez | Undead Rabbits | DROP | to FA | 10:30 am, 7/9/21 |
| Jeimer Candelario | The Bluth Company | DROP | to FA | 1:58 am, 7/9/21 |
| Miguel Diaz | Undead Rabbits | DROP | to FA | 12:32 am, 7/9/21 |
| Greg Holland | Shaolin Schmeckles | DROP | to FA | 7:49 pm, 7/8/21 |
| Nomar Mazara | Scranton Yankees | DROP | to FA | 12:34 pm, 7/8/21 |
| Jake Bauers | Bullet Club | DROP | to FA | 11:21 pm, 7/7/21 |
| Enrique Hernandez | Undead Rabbits | DROP | to FA | 1:38 pm, 7/7/21 |
| Jorge Lopez | Ye Olde Tom Toolshed | DROP | to FA | 11:13 am, 7/7/21 |
| Austin Voth | The Red Barons | DROP | to FA | 7:23 am, 7/7/21 |
| Jose Rojas | Shaolin Schmeckles | DROP | to FA | 3:27 am, 7/7/21 |
| Ken Waldichuk | The Bluth Company | DROP | to FA | 1:26 am, 7/7/21 |
| Yusmeiro Petit | Undead Rabbits | DROP | to FA | 11:44 pm, 7/6/21 |
| Austin Adams | Undead Rabbits | DROP | to FA | 11:44 pm, 7/6/21 |
| Alvarado Jose | Shaolin Schmeckles | DROP | to FA | 6:46 pm, 7/6/21 |
| Donovan Solano | Shaolin Schmeckles | DROP | to FA | 1:25 pm, 7/6/21 |
| Hector Neris | Shaolin Schmeckles | DROP | to FA | 11:51 am, 7/6/21 |
| Cristian Santana | Scranton Yankees | DROP | to FA | 7:04 am, 7/6/21 |
| Tucker Barnhart | Cowboys From Hell | DROP | to FA | 7:53 pm, 7/5/21 |
| Steven Duggar | Purple Cobras | DROP | to FA | 4:06 pm, 7/5/21 |
| Joey Lucchesi | Supreme Clientele | DROP | to FA | 3:36 pm, 7/5/21 |
| J.C. Mejia | Supreme Clientele | DROP | to FA | 3:35 pm, 7/5/21 |
| Tony Kemp | Supreme Clientele | DROP | to FA | 3:35 pm, 7/5/21 |
| Harold Ramirez | Supreme Clientele | DROP | to FA | 3:35 pm, 7/5/21 |
| Reese McGuire | Supreme Clientele | DROP | to FA | 3:35 pm, 7/5/21 |