| Player | Team | Action | Details | |
|---|---|---|---|---|
| Miguel Andujar | Geckos | DROP | to FA | 11:53 am, 7/5/21 |
| Jorge Alfaro | Geckos | DROP | to FA | 11:53 am, 7/5/21 |
| Max Kranick | The Bluth Company | DROP | to FA | 10:22 pm, 7/4/21 |
| Edmundo Sosa | Shaolin Schmeckles | DROP | to FA | 9:07 pm, 7/4/21 |
| Brent Rooker | Nixon's Nasty Ninjas | DROP | to FA | 12:49 pm, 7/4/21 |
| Elehuris Montero | Nixon's Nasty Ninjas | DROP | to FA | 12:33 pm, 7/4/21 |
| Adam Duvall | Scranton Yankees | DROP | to FA | 10:33 pm, 7/3/21 |
| Rougned Odor | Scranton Yankees | DROP | to FA | 10:33 pm, 7/3/21 |
| Chase De Jong | Scranton Yankees | DROP | to FA | 10:32 pm, 7/3/21 |
| Ervin Santana | Scranton Yankees | DROP | to FA | 10:32 pm, 7/3/21 |
| Darwinzon Hernandez | Shaolin Schmeckles | DROP | to FA | 2:55 pm, 7/2/21 |
| Jeimer Candelario | Bullet Club | DROP | to FA | 2:28 pm, 7/2/21 |
| Jahmai Jones | Supreme Clientele | DROP | to FA | 1:39 pm, 7/2/21 |
| Rodolfo Castro | Purple Cobras | DROP | to FA | 1:15 pm, 7/2/21 |
| Brent Suter | Shaolin Schmeckles | DROP | to FA | 4:14 am, 7/2/21 |
| Jared Jones | The Bluth Company | DROP | to FA | 11:21 pm, 7/1/21 |
| John Gant | Undead Rabbits | DROP | to FA | 1:24 pm, 7/1/21 |
| Odubel Herrera | Undead Rabbits | DROP | to FA | 1:24 pm, 7/1/21 |
| Michael Wacha | Supreme Clientele | DROP | to FA | 12:34 pm, 7/1/21 |
| Gabriel Arias | Supreme Clientele | DROP | to FA | 11:44 am, 7/1/21 |
| Yasel Antuna | The Red Barons | DROP | to FA | 8:00 pm, 6/30/21 |
| Billy McKinney | Geckos | DROP | to FA | 7:39 pm, 6/30/21 |
| Garrett Richards | The Red Barons | DROP | to FA | 1:34 pm, 6/30/21 |
| Rafael Montero | Cowboys From Hell | DROP | to FA | 12:53 pm, 6/30/21 |
| Freddy Galvis | Cowboys From Hell | DROP | to FA | 12:53 pm, 6/30/21 |