| Player | Team | Action | Details | |
|---|---|---|---|---|
| Aledmys Diaz | Purple Cobras | DROP | to FA | 7:13 pm, 8/27/21 |
| Jorge Mateo | The Red Barons | DROP | to FA | 12:21 pm, 8/27/21 |
| Jalen Beeks | The Red Barons | DROP | to FA | 12:21 pm, 8/27/21 |
| Brent Suter | The Red Barons | DROP | to FA | 12:20 pm, 8/27/21 |
| Jamie Barria | Cowboys From Hell | DROP | to FA | 5:54 am, 8/27/21 |
| Cal Raleigh | The Bluth Company | DROP | to FA | 1:08 am, 8/27/21 |
| Eli Morgan | The Bluth Company | DROP | to FA | 12:58 am, 8/27/21 |
| Dallas Keuchel | Ye Olde Tom Toolshed | DROP | to FA | 8:50 am, 8/26/21 |
| Cesar Hernandez | Ye Olde Tom Toolshed | DROP | to FA | 8:50 am, 8/26/21 |
| Seth Lugo | The Red Barons | DROP | to FA | 6:39 am, 8/26/21 |
| Lane Thomas | The Red Barons | DROP | to FA | 6:39 am, 8/26/21 |
| Corey Knebel | Shaolin Schmeckles | DROP | to FA | 3:03 am, 8/26/21 |
| Garrett Hampson | The Red Barons | DROP | to FA | 12:37 pm, 8/25/21 |
| Jose Suarez | Purple Cobras | DROP | to FA | 7:53 pm, 8/24/21 |
| Jed Lowrie | Cowboys From Hell | DROP | to FA | 9:11 am, 8/24/21 |
| Brent Rooker | The Red Barons | DROP | to FA | 8:59 am, 8/24/21 |
| Bradley Zimmer | The Red Barons | DROP | to FA | 8:59 am, 8/24/21 |
| Harrison Bader | The Red Barons | DROP | to FA | 8:59 am, 8/24/21 |
| Paul Blackburn | Shaolin Schmeckles | DROP | to FA | 3:13 am, 8/24/21 |
| Clayton Beeter | The Bluth Company | DROP | to FA | 12:02 am, 8/24/21 |
| Kevin Smith | The Bluth Company | DROP | to FA | 11:37 pm, 8/23/21 |
| Brian Rey | Ye Olde Tom Toolshed | DROP | to FA | 4:49 pm, 8/23/21 |
| Jacob Brentz | Shaolin Schmeckles | DROP | to FA | 4:39 pm, 8/23/21 |
| Rowan Wick | Geckos | DROP | to FA | 2:12 pm, 8/23/21 |
| Victor Gonzalez | Shaolin Schmeckles | DROP | to FA | 12:21 pm, 8/23/21 |