| Player | Team | Action | Details | |
|---|---|---|---|---|
| J.A. Happ | Supreme Clientele | DROP | to FA | 6:58 pm, 6/2/21 |
| Eric Lauer | Supreme Clientele | DROP | to FA | 6:58 pm, 6/2/21 |
| Vincent Velasquez | Supreme Clientele | DROP | to FA | 6:58 pm, 6/2/21 |
| Alex Colome | Shaolin Schmeckles | DROP | to FA | 6:47 pm, 6/2/21 |
| Yan Gomes | Purple Cobras | DROP | to FA | 5:06 pm, 6/2/21 |
| Hunter Brown | The Red Barons | DROP | to FA | 12:28 pm, 6/2/21 |
| Ronnie Dawson | The Bluth Company | DROP | to FA | 9:53 am, 6/2/21 |
| Brenton Doyle | The Bluth Company | DROP | to FA | 9:51 am, 6/2/21 |
| Cesar Valdez | Shaolin Schmeckles | DROP | to FA | 10:45 pm, 6/1/21 |
| Patrick Wisdom | Purple Cobras | DROP | to FA | 5:42 pm, 6/1/21 |
| Michael Wacha | Supreme Clientele | DROP | to FA | 4:06 pm, 6/1/21 |
| Jordan Lyles | Supreme Clientele | DROP | to FA | 4:06 pm, 6/1/21 |
| Joshua Mears | Geckos | DROP | to FA | 1:49 pm, 6/1/21 |
| Tylor Megill | Geckos | DROP | to FA | 1:27 pm, 6/1/21 |
| Lyon Richardson | The Bluth Company | DROP | to FA | 1:13 pm, 6/1/21 |
| Luis Garcia | Chinballs | DROP | to FA | 10:45 am, 6/1/21 |
| C.J. Van Eyk | Purple Cobras | DROP | to FA | 9:36 am, 6/1/21 |
| Ji-Man Choi | Purple Cobras | DROP | to FA | 8:39 am, 6/1/21 |
| Niko Goodrum | Shaolin Schmeckles | DROP | to FA | 11:08 pm, 5/31/21 |
| Travis Shaw | Scranton Yankees | DROP | to FA | 9:19 pm, 5/31/21 |
| Evan Carter | The Bluth Company | DROP | to FA | 9:16 pm, 5/31/21 |
| Jon Lester | Supreme Clientele | DROP | to FA | 12:41 pm, 5/31/21 |
| Josh Harrison | Supreme Clientele | DROP | to FA | 12:41 pm, 5/31/21 |
| Luis Frias | The Bluth Company | DROP | to FA | 12:38 pm, 5/31/21 |
| Michael Baumann | The Bluth Company | DROP | to FA | 12:19 pm, 5/31/21 |