| Player | Team | Action | Details | |
|---|---|---|---|---|
| Kyle Isbel | Purple Cobras | DROP | to FA | 1:02 pm, 5/22/21 |
| Tanner Rainey | The Red Barons | DROP | to FA | 10:03 am, 5/22/21 |
| Jose De Leon | Scranton Yankees | DROP | to FA | 10:04 pm, 5/21/21 |
| Corey Knebel | Scranton Yankees | DROP | to FA | 10:04 pm, 5/21/21 |
| Kevin Pillar | Scranton Yankees | DROP | to FA | 10:03 pm, 5/21/21 |
| Myles Straw | Shaolin Schmeckles | DROP | to FA | 4:59 pm, 5/21/21 |
| Sam Hentges | Supreme Clientele | DROP | to FA | 2:46 pm, 5/21/21 |
| Jonathan Villar | Supreme Clientele | DROP | to FA | 2:45 pm, 5/21/21 |
| Josh Harrison | Supreme Clientele | DROP | to FA | 2:45 pm, 5/21/21 |
| Kolten Wong | Supreme Clientele | DROP | to FA | 2:44 pm, 5/21/21 |
| Ryan Jeffers | Supreme Clientele | DROP | to FA | 1:51 pm, 5/21/21 |
| Harold Ramirez | The Bluth Company | DROP | to FA | 1:22 pm, 5/21/21 |
| Jonatan Clase | Chinballs | DROP | to FA | 11:54 am, 5/21/21 |
| Franklin Perez | Scranton Yankees | DROP | to FA | 6:47 am, 5/21/21 |
| Aaron Ashby | Undead Rabbits | DROP | to FA | 12:09 am, 5/21/21 |
| Domingo Leyba | Shaolin Schmeckles | DROP | to FA | 12:04 am, 5/21/21 |
| Gilberto Celestino | Shaolin Schmeckles | DROP | to FA | 2:55 pm, 5/20/21 |
| Matt Beaty | Cowboys From Hell | DROP | to FA | 10:07 am, 5/20/21 |
| Bailey Ober | Purple Cobras | DROP | to FA | 7:47 am, 5/20/21 |
| Evan Longoria | Undead Rabbits | DROP | to FA | 12:00 am, 5/20/21 |
| Albert Pujols | Undead Rabbits | DROP | to FA | 11:58 pm, 5/19/21 |
| Cole Sands | Purple Cobras | DROP | to FA | 11:51 am, 5/19/21 |
| Stephen Gonsalves | Bullet Club | DROP | to FA | 11:48 am, 5/19/21 |
| Aaron Ashby | Purple Cobras | DROP | to FA | 11:44 am, 5/19/21 |
| Michael Baumann | The Bluth Company | DROP | to FA | 9:48 am, 5/19/21 |