| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jose Peraza | Nixon's Nasty Ninjas | DROP | to FA | 9:22 am, 5/18/21 |
| Jed Lowrie | The Bluth Company | DROP | to FA | 1:09 pm, 5/17/21 |
| Tyler Duffey | Nixon's Nasty Ninjas | DROP | to FA | 1:07 pm, 5/17/21 |
| Masyn Winn | The Bluth Company | DROP | to FA | 1:07 pm, 5/17/21 |
| Seth Brown | The Bluth Company | DROP | to FA | 11:38 am, 5/17/21 |
| Will Craig | The Bluth Company | DROP | to FA | 11:37 am, 5/17/21 |
| Jimmy Nelson | Purple Cobras | DROP | to FA | 11:04 am, 5/17/21 |
| Alex Cobb | The Red Barons | DROP | to FA | 6:28 am, 5/17/21 |
| Patrick Sandoval | The Red Barons | DROP | to FA | 6:25 am, 5/17/21 |
| Yusmeiro Petit | Undead Rabbits | DROP | to FA | 6:05 pm, 5/16/21 |
| Alex Colome | Undead Rabbits | DROP | to FA | 12:25 pm, 5/16/21 |
| Jonathan Loaisiga | Undead Rabbits | DROP | to FA | 12:24 pm, 5/16/21 |
| Keone Kela | Undead Rabbits | DROP | to FA | 12:24 pm, 5/16/21 |
| Franchy Cordero | Undead Rabbits | DROP | to FA | 12:24 pm, 5/16/21 |
| Tyrone Taylor | Chinballs | DROP | to FA | 9:17 am, 5/16/21 |
| Marwin Gonzalez | Chinballs | DROP | to FA | 9:16 am, 5/16/21 |
| Mitch Moreland | Cowboys From Hell | DROP | to FA | 8:54 am, 5/16/21 |
| Miguel Rojas | Purple Cobras | DROP | to FA | 7:05 am, 5/16/21 |
| Rowdy Tellez | The Red Barons | DROP | to FA | 4:07 pm, 5/15/21 |
| Wilson Ramos | Cowboys From Hell | DROP | to FA | 1:26 pm, 5/15/21 |
| Freddy Galvis | Purple Cobras | DROP | to FA | 6:49 am, 5/15/21 |
| Adam Frazier | Cowboys From Hell | DROP | to FA | 7:17 pm, 5/14/21 |
| Freddy Galvis | Cowboys From Hell | DROP | to FA | 7:17 pm, 5/14/21 |
| Corey Dickerson | Purple Cobras | DROP | to FA | 7:06 pm, 5/14/21 |
| Matt Duffy | Bullet Club | DROP | to FA | 1:03 pm, 5/14/21 |