| Player | Team | Action | Details | |
|---|---|---|---|---|
| Ryan Helsley | Cowboys From Hell | DROP | to FA | 10:10 am, 5/10/21 |
| A.J. Minter | Cowboys From Hell | DROP | to FA | 9:55 am, 5/10/21 |
| Christian Arroyo | The Red Barons | DROP | to FA | 9:09 am, 5/10/21 |
| Yadiel Hernandez | The Bluth Company | DROP | to FA | 11:34 pm, 5/9/21 |
| Lorenzo Cain | Shaolin Schmeckles | DROP | to FA | 8:08 pm, 5/9/21 |
| Nick Gordon | Purple Cobras | DROP | to FA | 4:05 pm, 5/9/21 |
| Erik Swanson | Cowboys From Hell | DROP | to FA | 1:40 pm, 5/9/21 |
| Jackie Bradley Jr | Bullet Club | DROP | to FA | 11:43 am, 5/9/21 |
| Tylor Megill | Geckos | DROP | to FA | 2:30 am, 5/9/21 |
| Edwin Uceta | Geckos | DROP | to FA | 2:21 am, 5/9/21 |
| Joey Cantillo | The Bluth Company | DROP | to FA | 8:56 pm, 5/8/21 |
| Kevin Maitan | Bridge Four | DROP | to FA | 6:46 pm, 5/8/21 |
| Brice Turang | Bridge Four | DROP | to FA | 6:42 pm, 5/8/21 |
| Kyle Higashioka | The Bluth Company | DROP | to FA | 2:36 pm, 5/8/21 |
| Alexander Vizcaino | Purple Cobras | DROP | to FA | 12:53 pm, 5/8/21 |
| Jordan Luplow | Chinballs | DROP | to FA | 11:34 am, 5/8/21 |
| Lewis Brinson | Chinballs | DROP | to FA | 11:17 am, 5/8/21 |
| Martin Perez | The Bluth Company | DROP | to FA | 11:02 am, 5/8/21 |
| Michael Tauchman | The Bluth Company | DROP | to FA | 10:59 am, 5/8/21 |
| Sheldon Neuse | Cowboys From Hell | DROP | to FA | 9:28 am, 5/8/21 |
| Rafael Montero | Purple Cobras | DROP | to FA | 8:59 am, 5/8/21 |
| Braden Shewmake | Supreme Clientele | DROP | to FA | 2:01 am, 5/8/21 |
| Trevor Williams | Supreme Clientele | DROP | to FA | 2:01 am, 5/8/21 |
| Rowdy Tellez | The Bluth Company | DROP | to FA | 12:13 am, 5/8/21 |
| Dan Vogelbach | Supreme Clientele | DROP | to FA | 9:58 pm, 5/7/21 |