| Player | Team | Action | Details | |
|---|---|---|---|---|
| Ivan Herrera | Supreme Clientele | DROP | to FA | 9:58 pm, 5/7/21 |
| Justin Upton | Undead Rabbits | DROP | to FA | 8:39 pm, 5/7/21 |
| Jairo Solis | Shaolin Schmeckles | DROP | to FA | 8:18 pm, 5/7/21 |
| Erick Fedde | Cowboys From Hell | DROP | to FA | 4:08 pm, 5/7/21 |
| Yadiel Hernandez | Cowboys From Hell | DROP | to FA | 4:08 pm, 5/7/21 |
| Paredes Enoli | Shaolin Schmeckles | DROP | to FA | 3:03 pm, 5/7/21 |
| Jhon Torres | The Bluth Company | DROP | to FA | 1:06 pm, 5/7/21 |
| Carmen Mlodzinski | The Bluth Company | DROP | to FA | 12:22 pm, 5/7/21 |
| Victor Gonzalez | Bullet Club | DROP | to FA | 7:05 am, 5/7/21 |
| Ryan Zimmerman | Scranton Yankees | DROP | to FA | 5:10 pm, 5/6/21 |
| Isan Diaz | Purple Cobras | DROP | to FA | 4:16 pm, 5/6/21 |
| Tony Santillan | The Bluth Company | DROP | to FA | 3:33 pm, 5/6/21 |
| Drew Strotman | The Bluth Company | DROP | to FA | 12:52 pm, 5/6/21 |
| Wilmer Flores | Shaolin Schmeckles | DROP | to FA | 12:48 pm, 5/6/21 |
| Lewis Thorpe | Purple Cobras | DROP | to FA | 12:18 pm, 5/6/21 |
| Justin Williams | Chinballs | DROP | to FA | 11:07 am, 5/6/21 |
| Michael Fulmer | Chinballs | DROP | to FA | 10:31 am, 5/6/21 |
| Yoendrys Gomez | The Bluth Company | DROP | to FA | 10:18 am, 5/6/21 |
| Trevor May | Purple Cobras | DROP | to FA | 6:07 am, 5/6/21 |
| Alec Mills | The Bluth Company | DROP | to FA | 2:44 pm, 5/5/21 |
| Renato Nunez | Undead Rabbits | DROP | to FA | 1:36 pm, 5/5/21 |
| Seth Brown | The Bluth Company | DROP | to FA | 1:05 pm, 5/5/21 |
| Alex Dickerson | Purple Cobras | DROP | to FA | 12:51 pm, 5/5/21 |
| Yoenis Cespedes | Scranton Yankees | DROP | to FA | 9:29 am, 5/5/21 |
| Donovan Solano | Scranton Yankees | DROP | to FA | 9:29 am, 5/5/21 |