| Player | Team | Action | Details | |
|---|---|---|---|---|
| Sheldon Neuse | Cowboys From Hell | DROP | to FA | 9:28 am, 5/8/21 |
| Rafael Montero | Purple Cobras | DROP | to FA | 8:59 am, 5/8/21 |
| Braden Shewmake | Supreme Clientele | DROP | to FA | 2:01 am, 5/8/21 |
| Trevor Williams | Supreme Clientele | DROP | to FA | 2:01 am, 5/8/21 |
| Rowdy Tellez | The Bluth Company | DROP | to FA | 12:13 am, 5/8/21 |
| Dan Vogelbach | Supreme Clientele | DROP | to FA | 9:58 pm, 5/7/21 |
| Ivan Herrera | Supreme Clientele | DROP | to FA | 9:58 pm, 5/7/21 |
| Justin Upton | Undead Rabbits | DROP | to FA | 8:39 pm, 5/7/21 |
| Jairo Solis | Shaolin Schmeckles | DROP | to FA | 8:18 pm, 5/7/21 |
| Erick Fedde | Cowboys From Hell | DROP | to FA | 4:08 pm, 5/7/21 |
| Yadiel Hernandez | Cowboys From Hell | DROP | to FA | 4:08 pm, 5/7/21 |
| Paredes Enoli | Shaolin Schmeckles | DROP | to FA | 3:03 pm, 5/7/21 |
| Jhon Torres | The Bluth Company | DROP | to FA | 1:06 pm, 5/7/21 |
| Carmen Mlodzinski | The Bluth Company | DROP | to FA | 12:22 pm, 5/7/21 |
| Victor Gonzalez | Bullet Club | DROP | to FA | 7:05 am, 5/7/21 |
| Ryan Zimmerman | Scranton Yankees | DROP | to FA | 5:10 pm, 5/6/21 |
| Isan Diaz | Purple Cobras | DROP | to FA | 4:16 pm, 5/6/21 |
| Tony Santillan | The Bluth Company | DROP | to FA | 3:33 pm, 5/6/21 |
| Drew Strotman | The Bluth Company | DROP | to FA | 12:52 pm, 5/6/21 |
| Wilmer Flores | Shaolin Schmeckles | DROP | to FA | 12:48 pm, 5/6/21 |
| Lewis Thorpe | Purple Cobras | DROP | to FA | 12:18 pm, 5/6/21 |
| Justin Williams | Chinballs | DROP | to FA | 11:07 am, 5/6/21 |
| Michael Fulmer | Chinballs | DROP | to FA | 10:31 am, 5/6/21 |
| Yoendrys Gomez | The Bluth Company | DROP | to FA | 10:18 am, 5/6/21 |
| Trevor May | Purple Cobras | DROP | to FA | 6:07 am, 5/6/21 |