| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jonathan Schoop | Shaolin Schmeckles | DROP | to FA | 9:00 am, 4/25/21 |
| Miguel Rojas | Purple Cobras | DROP | to FA | 7:05 am, 4/24/21 |
| Asdrubal Cabrera | Undead Rabbits | DROP | to FA | 5:34 pm, 4/23/21 |
| Jake Diekman | Cowboys From Hell | DROP | to FA | 12:20 pm, 4/23/21 |
| Taylor Hearn | Kimble's Kids | DROP | to FA | 12:17 pm, 4/23/21 |
| Martin Perez | Kimble's Kids | DROP | to FA | 12:16 pm, 4/23/21 |
| Miguel Cabrera | Undead Rabbits | DROP | to FA | 12:09 pm, 4/23/21 |
| Nick Pivetta | Undead Rabbits | DROP | to FA | 12:08 pm, 4/23/21 |
| Adam Duvall | Undead Rabbits | DROP | to FA | 12:08 pm, 4/23/21 |
| Ryan Jeffers | The Bluth Company | DROP | to FA | 12:54 am, 4/23/21 |
| Junior Fernandez | Ye Olde Tom Toolshed | DROP | to FA | 10:48 am, 4/22/21 |
| Sean Reid-Foley | Ye Olde Tom Toolshed | DROP | to FA | 10:48 am, 4/22/21 |
| Joey Cantillo | Bullet Club | DROP | to FA | 10:35 am, 4/22/21 |
| Aledmys Diaz | Geckos | DROP | to FA | 10:17 am, 4/22/21 |
| Justin Williams | The Bluth Company | DROP | to FA | 8:57 pm, 4/21/21 |
| Kyle Harrison | The Bluth Company | DROP | to FA | 7:15 pm, 4/21/21 |
| Tyler Matzek | Geckos | DROP | to FA | 3:01 pm, 4/21/21 |
| Yandy Diaz | Geckos | DROP | to FA | 3:00 pm, 4/21/21 |
| Jonathan Villar | Shaolin Schmeckles | DROP | to FA | 2:30 pm, 4/21/21 |
| Brett Anderson | Shaolin Schmeckles | DROP | to FA | 2:29 pm, 4/21/21 |
| Rowdy Tellez | Purple Cobras | DROP | to FA | 2:19 pm, 4/21/21 |
| Lewis Thorpe | The Bluth Company | DROP | to FA | 10:31 pm, 4/20/21 |
| Randal Grichuk | Purple Cobras | DROP | to FA | 12:06 pm, 4/20/21 |
| Tyler Beede | The Red Barons | DROP | to FA | 9:35 am, 4/20/21 |
| Zack Burdi | The Bluth Company | DROP | to FA | 9:17 pm, 4/19/21 |