| Player | Team | Action | Details | |
|---|---|---|---|---|
| Yadier Molina | Jon Voight's Car | ADD | to MLB | 11:16 pm, 4/4/22 |
| Seth Johnson | Nixon's Nasty Ninjas | ADD | to AAA | 11:16 pm, 4/4/22 |
| Nicky Lopez | Bullet Club | ADD | to MLB | 11:11 pm, 4/4/22 |
| Adrian Houser | Bullet Club | ADD | to MLB | 11:10 pm, 4/4/22 |
| Jorge Mateo | Monk's Café | ADD | to MLB | 11:09 pm, 4/4/22 |
| Nick Solak | Undead Rabbits | ADD | to MLB | 11:09 pm, 4/4/22 |
| Zach Thompson | Chinballs | ADD | to MLB | 11:09 pm, 4/4/22 |
| Robbie Grossman | Cowboys From Hell | ADD | to MLB | 11:07 pm, 4/4/22 |
| Chris Archer | Supreme Clientele | ADD | to MLB | 11:02 pm, 4/4/22 |
| David Peralta | Ye Olde Tom Toolshed | ADD | to MLB | 11:01 pm, 4/4/22 |
| Ivan Herrera | The Red Barons | ADD | to MLB | 11:01 pm, 4/4/22 |
| Johan Rojas | Bullet Club | ADD | to MLB | 10:55 pm, 4/4/22 |
| Dillon Tate | Monk's Café | ADD | to MLB | 10:55 pm, 4/4/22 |
| Michael Wacha | Supreme Clientele | ADD | to MLB | 10:55 pm, 4/4/22 |
| Amir Garrett | Undead Rabbits | ADD | to MLB | 10:54 pm, 4/4/22 |
| Nolan Jones | Cowboys From Hell | ADD | to MLB | 10:49 pm, 4/4/22 |
| Nick Martinez | Supreme Clientele | ADD | to MLB | 10:43 pm, 4/4/22 |
| Ryan Yarbrough | Chinballs | ADD | to MLB | 10:43 pm, 4/4/22 |
| Enrique Hernandez | Undead Rabbits | ADD | to MLB | 10:42 pm, 4/4/22 |
| Randal Grichuk | Monk's Café | ADD | to MLB | 10:41 pm, 4/4/22 |
| James Paxton | The Red Barons | ADD | to MLB | 10:39 pm, 4/4/22 |
| Andrew Kittredge | Geckos | ADD | to MLB | 10:39 pm, 4/4/22 |
| Mickey Moniak | Jon Voight's Car | ADD | to MLB | 10:36 pm, 4/4/22 |
| Eric Lauer | Nixon's Nasty Ninjas | ADD | to MLB | 10:36 pm, 4/4/22 |
| Corey Knebel | Geckos | ADD | to MLB | 10:35 pm, 4/4/22 |