| Player | Team | Action | Details | |
|---|---|---|---|---|
| Mike Yastrzemski | The Bluth Company | ADD | to MLB | 10:35 pm, 4/4/22 |
| Scott Barlow | The Red Barons | ADD | to MLB | 10:35 pm, 4/4/22 |
| Chris Archer | Undead Rabbits | ADD | to MLB | 2:06 pm, 3/24/22 |
| Aeverson Arteaga | The Bluth Company | ADD | to AA | 9:51 am, 3/24/22 |
| Jonathan Loaisiga | Chinballs | ADD | to MLB | 10:45 pm, 3/17/22 |
| Rowdy Tellez | Scranton Yankees | ADD | to MLB | 11:07 pm, 3/15/22 |
| Matt Barnes | Undead Rabbits | ADD | to NA | 9:23 am, 3/15/22 |
| Adam Engel | Ye Olde Tom Toolshed | ADD | to MLB | 7:54 pm, 3/14/22 |
| Jake McGee | Purple Cobras | ADD | to MLB | 4:41 pm, 2/20/22 |
| Michael Chavis | Purple Cobras | ADD | to AAA | 4:41 pm, 2/20/22 |
| Miguel Yajure | Purple Cobras | ADD | to MLB | 4:41 pm, 2/20/22 |
| Lou Trivino | Purple Cobras | ADD | to MLB | 4:41 pm, 2/20/22 |
| Jake Diekman | Purple Cobras | ADD | to MLB | 4:40 pm, 2/20/22 |
| Lucas Sims | Purple Cobras | ADD | to MLB | 4:39 pm, 2/20/22 |
| Jorge Ona | Purple Cobras | ADD | to A | 4:39 pm, 2/20/22 |
| Connor Joe | Purple Cobras | ADD | to AAA | 4:39 pm, 2/20/22 |
| Bryan De La Cruz | Purple Cobras | ADD | to MLB | 4:39 pm, 2/20/22 |
| Justin Upton | Purple Cobras | ADD | to MLB | 4:39 pm, 2/20/22 |
| Samad Taylor | Purple Cobras | ADD | to AA | 4:39 pm, 2/20/22 |
| Andres Munoz | Purple Cobras | ADD | to AAA | 4:38 pm, 2/20/22 |
| Sean Murphy | Purple Cobras | ADD | to MLB | 4:38 pm, 2/20/22 |
| Yonny Chirinos | Purple Cobras | ADD | to MLB | 4:38 pm, 2/20/22 |
| Cole Sands | Purple Cobras | ADD | to AAA | 4:38 pm, 2/20/22 |
| Jake Meyers | Purple Cobras | ADD | to MLB | 4:38 pm, 2/20/22 |
| Connor Seabold | Purple Cobras | ADD | to AAA | 4:38 pm, 2/20/22 |