| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jay Bruce | Geckos | ADD | to MLB | 12:41 pm, 4/5/21 |
| Trevor May | Geckos | ADD | to MLB | 12:40 pm, 4/5/21 |
| Miguel Rojas | Purple Cobras | ADD | to MLB | 10:03 am, 4/5/21 |
| Max Stassi | Purple Cobras | ADD | to MLB | 7:32 am, 4/5/21 |
| Cedric Mullins | Purple Cobras | ADD | to MLB | 4:21 pm, 4/4/21 |
| Zach McKinstry | The Bluth Company | ADD | to AAA | 12:27 pm, 4/4/21 |
| Brett Anderson | Supreme Clientele | ADD | to MLB | 11:43 am, 4/4/21 |
| Max Stassi | Purple Cobras | ADD | to MLB | 3:52 am, 4/4/21 |
| Miguel Cabrera | Purple Cobras | ADD | to MLB | 3:41 am, 4/4/21 |
| Jason Heyward | Purple Cobras | ADD | to MLB | 2:27 am, 4/4/21 |
| Josh Staumont | Geckos | ADD | to MLB | 6:43 pm, 4/3/21 |
| Danny Duffy | Geckos | ADD | to MLB | 6:43 pm, 4/3/21 |
| Bruce Zimmermann | The Bluth Company | ADD | to MLB | 6:41 pm, 4/3/21 |
| Jonathan Loaisiga | The Bluth Company | ADD | to MLB | 6:05 pm, 4/3/21 |
| Cesar Valdez | Shaolin Schmeckles | ADD | to MLB | 4:04 pm, 4/3/21 |
| Yermin Mercedes | The Bluth Company | ADD | to AAA | 2:04 am, 4/3/21 |
| Luis Gil | Geckos | ADD | to AA | 1:55 am, 4/3/21 |
| Mitch Moreland | Geckos | ADD | to MLB | 1:46 am, 4/3/21 |
| Taylor Widener | The Bluth Company | ADD | to AAA | 10:27 pm, 4/2/21 |
| Connor Seabold | Purple Cobras | ADD | to AAA | 7:27 pm, 4/2/21 |
| David Bednar | The Bluth Company | ADD | to AAA | 7:26 pm, 4/2/21 |
| Joey Wendle | Cowboys From Hell | ADD | to MLB | 5:07 pm, 4/2/21 |
| Donovan Solano | Scranton Yankees | ADD | to MLB | 2:17 pm, 4/2/21 |
| Julio Teheran | Scranton Yankees | ADD | to MLB | 2:15 pm, 4/2/21 |
| Thomas Szapucki | Scranton Yankees | ADD | to AA | 2:14 pm, 4/2/21 |