| Player | Team | Action | Details | |
|---|---|---|---|---|
| Edwin Rios | Chinballs | DROP | to FA | 8:20 pm, 8/21/22 |
| Rich Hill | Chinballs | DROP | to FA | 8:19 pm, 8/21/22 |
| Mark Melancon | Ye Olde Tom Toolshed | DROP | to FA | 7:30 am, 8/21/22 |
| Michael Burrows | The Bluth Company | DROP | to FA | 6:40 pm, 8/19/22 |
| Ramon Urias | Cowboys From Hell | DROP | to FA | 3:23 pm, 8/19/22 |
| Peyton Burdick | The Bluth Company | DROP | to FA | 12:14 pm, 8/19/22 |
| Terrin Vavra | The Bluth Company | DROP | to FA | 12:14 pm, 8/19/22 |
| Yasmani Grandal | The Bluth Company | DROP | to FA | 12:14 pm, 8/19/22 |
| Taylor Rogers | Shaolin Schmeckles | DROP | to FA | 7:45 am, 8/19/22 |
| Jurickson Profar | Shaolin Schmeckles | DROP | to FA | 7:45 am, 8/19/22 |
| Christian Vazquez | Undead Rabbits | DROP | to FA | 11:45 am, 8/18/22 |
| Emmet Sheehan | The Bluth Company | DROP | to FA | 10:30 am, 8/18/22 |
| Nelson Velasquez | Chinballs | DROP | to FA | 1:49 am, 8/18/22 |
| Stone Garrett | Chinballs | DROP | to FA | 1:49 am, 8/18/22 |
| A.J. Minter | Chinballs | DROP | to FA | 11:40 am, 8/17/22 |
| JT Brubaker | The Bluth Company | DROP | to FA | 12:12 pm, 8/16/22 |
| Josh Smith | The Bluth Company | DROP | to FA | 12:11 pm, 8/16/22 |
| Brandon Belt | The Bluth Company | DROP | to FA | 12:10 pm, 8/16/22 |
| Heston Kjerstad | The Bluth Company | DROP | to FA | 10:24 am, 8/16/22 |
| Wilman Diaz | Bullet Club | DROP | to FA | 12:28 pm, 8/15/22 |
| Lewin Diaz | The Red Barons | DROP | to FA | 9:36 am, 8/15/22 |
| J.P. Crawford | Bullet Club | DROP | to FA | 9:30 pm, 8/14/22 |
| Kyle Finnegan | Chinballs | DROP | to FA | 10:47 am, 8/14/22 |
| Dan Jansen | Chinballs | DROP | to FA | 10:38 am, 8/14/22 |
| Jaylin Davis | Undead Rabbits | DROP | to FA | 10:23 am, 8/14/22 |