| Player | Team | Action | Details | |
|---|---|---|---|---|
| Brett Anderson | Bridge Four | DROP | to FA | 9:17 pm, 3/25/22 |
| Jose Urena | Bridge Four | DROP | to FA | 9:16 pm, 3/25/22 |
| Jon Lester | Bridge Four | DROP | to FA | 9:15 pm, 3/25/22 |
| David Peralta | Bridge Four | DROP | to FA | 9:13 pm, 3/25/22 |
| Jon Berti | Bridge Four | DROP | to FA | 9:10 pm, 3/25/22 |
| Asdrubal Cabrera | Bridge Four | DROP | to FA | 9:09 pm, 3/25/22 |
| Yan Gomes | Bridge Four | DROP | to FA | 9:08 pm, 3/25/22 |
| Robert Puason | Scranton Yankees | DROP | to FA | 12:09 am, 3/25/22 |
| Thomas Szapucki | Scranton Yankees | DROP | to FA | 12:07 am, 3/25/22 |
| Kyle Freeland | Scranton Yankees | DROP | to FA | 12:03 am, 3/25/22 |
| James McCann | Scranton Yankees | DROP | to FA | 12:03 am, 3/25/22 |
| Enrique Hernandez | Scranton Yankees | DROP | to FA | 12:00 am, 3/25/22 |
| Mason Denaburg | Kimble's Kids | DROP | to FA | 11:47 pm, 3/24/22 |
| Yusniel Diaz | Kimble's Kids | DROP | to FA | 11:42 pm, 3/24/22 |
| T.J. Zeuch | Kimble's Kids | DROP | to FA | 11:42 pm, 3/24/22 |
| Amir Garrett | Kimble's Kids | DROP | to FA | 11:42 pm, 3/24/22 |
| Andy Ibanez | Kimble's Kids | DROP | to FA | 11:41 pm, 3/24/22 |
| Kolby Allard | Kimble's Kids | DROP | to FA | 11:41 pm, 3/24/22 |
| Cole Hamels | Kimble's Kids | DROP | to FA | 11:41 pm, 3/24/22 |
| Chris Archer | Undead Rabbits | DROP | to FA | 11:01 pm, 3/24/22 |
| Trevor Cahill | Kimble's Kids | DROP | to FA | 11:00 pm, 3/24/22 |
| Kwang-Hyun Kim | Kimble's Kids | DROP | to FA | 10:58 pm, 3/24/22 |
| Braxton Garrett | Kimble's Kids | DROP | to FA | 10:55 pm, 3/24/22 |
| Dietrich Enns | Kimble's Kids | DROP | to FA | 10:41 pm, 3/24/22 |
| Michael Chavis | Purple Cobras | DROP | to FA | 10:10 pm, 3/24/22 |