| Player | Team | Action | Details | |
|---|---|---|---|---|
| Miguel Yajure | Purple Cobras | DROP | to FA | 10:10 pm, 3/24/22 |
| Andres Munoz | Purple Cobras | DROP | to FA | 10:10 pm, 3/24/22 |
| Jorge Ona | Purple Cobras | DROP | to FA | 10:10 pm, 3/24/22 |
| Jake Diekman | Purple Cobras | DROP | to FA | 10:10 pm, 3/24/22 |
| Brusdar Graterol | Geckos | DROP | to FA | 9:54 pm, 3/24/22 |
| Miguel Cabrera | Kimble's Kids | DROP | to FA | 9:46 pm, 3/24/22 |
| Khris Davis | Kimble's Kids | DROP | to FA | 9:46 pm, 3/24/22 |
| Jared Kelley | Geckos | DROP | to FA | 9:39 pm, 3/24/22 |
| Cole Wilcox | Geckos | DROP | to FA | 9:36 pm, 3/24/22 |
| Eric Hosmer | Geckos | DROP | to FA | 9:32 pm, 3/24/22 |
| Jake Burger | Geckos | DROP | to FA | 9:31 pm, 3/24/22 |
| Diego Castillo | Geckos | DROP | to FA | 9:30 pm, 3/24/22 |
| Will Smith | Geckos | DROP | to FA | 9:30 pm, 3/24/22 |
| Ryan Jeffers | Geckos | DROP | to FA | 9:30 pm, 3/24/22 |
| Nick Solak | Geckos | DROP | to FA | 9:30 pm, 3/24/22 |
| Kyle Seager | Cowboys From Hell | DROP | to FA | 4:54 pm, 3/24/22 |
| Clayton Beeter | Cowboys From Hell | DROP | to FA | 4:54 pm, 3/24/22 |
| Reynaldo Lopez | Cowboys From Hell | DROP | to FA | 4:53 pm, 3/24/22 |
| Kohei Arihara | Cowboys From Hell | DROP | to FA | 4:53 pm, 3/24/22 |
| Chas McCormick | Cowboys From Hell | DROP | to FA | 4:53 pm, 3/24/22 |
| Odubel Herrera | Cowboys From Hell | DROP | to FA | 4:53 pm, 3/24/22 |
| Randal Grichuk | Cowboys From Hell | DROP | to FA | 4:53 pm, 3/24/22 |
| Yu Chang | Cowboys From Hell | DROP | to FA | 4:53 pm, 3/24/22 |
| Francisco Mejia | Cowboys From Hell | DROP | to FA | 4:53 pm, 3/24/22 |
| Yasiel Puig | Cowboys From Hell | DROP | to FA | 4:52 pm, 3/24/22 |