| Player | Team | Action | Details | |
|---|---|---|---|---|
| Kyle Cody | The Red Barons | DROP | to FA | 7:06 am, 1/20/22 |
| Jorge Mateo | The Red Barons | DROP | to FA | 7:06 am, 1/20/22 |
| Jalen Beeks | The Red Barons | DROP | to FA | 7:06 am, 1/20/22 |
| David Fletcher | The Red Barons | DROP | to FA | 7:05 am, 1/20/22 |
| Yandy Diaz | The Red Barons | DROP | to FA | 7:05 am, 1/20/22 |
| Alex Canario | Undead Rabbits | DROP | to FA | 1:18 am, 1/20/22 |
| Kendall Graveman | Undead Rabbits | DROP | to FA | 1:09 am, 1/20/22 |
| Josh Rogers | Undead Rabbits | DROP | to FA | 1:05 am, 1/20/22 |
| Freudis Nova | Undead Rabbits | DROP | to FA | 1:03 am, 1/20/22 |
| Cody Poteet | Undead Rabbits | DROP | to FA | 1:02 am, 1/20/22 |
| Jesus Galiz | Undead Rabbits | DROP | to FA | 1:00 am, 1/20/22 |
| Johan Oviedo | Undead Rabbits | DROP | to FA | 8:30 am, 1/19/22 |
| Armando Cruz | Undead Rabbits | DROP | to FA | 7:54 am, 1/19/22 |
| Evan Longoria | Undead Rabbits | DROP | to FA | 7:52 am, 1/19/22 |
| Bo Naylor | Undead Rabbits | DROP | to FA | 7:52 am, 1/19/22 |
| Danny Duffy | Geckos | DROP | to FA | 6:49 pm, 1/18/22 |
| Nick Anderson | Geckos | DROP | to FA | 6:48 pm, 1/18/22 |
| Seth Romero | Geckos | DROP | to FA | 6:47 pm, 1/18/22 |
| Brian Anderson | Geckos | DROP | to FA | 6:46 pm, 1/18/22 |
| Matt Wisler | The Bluth Company | DROP | to FA | 3:39 pm, 1/18/22 |
| Jose Devers | Scranton Yankees | DROP | to FA | 11:07 pm, 1/14/22 |
| Jordan Lyles | Scranton Yankees | DROP | to FA | 11:06 pm, 1/14/22 |
| Will Crowe | Scranton Yankees | DROP | to FA | 11:04 pm, 1/14/22 |
| Michael Wacha | Scranton Yankees | DROP | to FA | 11:04 pm, 1/14/22 |
| Jake Arrieta | Scranton Yankees | DROP | to FA | 11:03 pm, 1/14/22 |