| Player | Team | Action | Details | |
|---|---|---|---|---|
| Michael A. Taylor | Scranton Yankees | DROP | to FA | 11:03 pm, 1/14/22 |
| Donovan Solano | Scranton Yankees | DROP | to FA | 11:03 pm, 1/14/22 |
| Rowdy Tellez | Scranton Yankees | DROP | to FA | 11:03 pm, 1/14/22 |
| Drew Smyly | Supreme Clientele | DROP | to FA | 4:13 pm, 1/14/22 |
| Scott Barlow | Supreme Clientele | DROP | to FA | 4:12 pm, 1/14/22 |
| Bryse Wilson | Supreme Clientele | DROP | to FA | 4:12 pm, 1/14/22 |
| Luis Torrens | Supreme Clientele | DROP | to FA | 4:12 pm, 1/14/22 |
| Joe Ross | Supreme Clientele | DROP | to FA | 3:33 pm, 1/13/22 |
| Max Schrock | Undead Rabbits | DROP | to FA | 5:04 pm, 1/11/22 |
| Felix Pena | Bridge Four | DROP | to FA | 4:52 pm, 1/10/22 |
| Anthony Banda | Bridge Four | DROP | to FA | 4:51 pm, 1/10/22 |
| Travis Bergen | Bridge Four | DROP | to FA | 4:51 pm, 1/10/22 |
| Stephen Piscotty | Bridge Four | DROP | to FA | 4:50 pm, 1/10/22 |
| Nick Gordon | Bridge Four | DROP | to FA | 4:50 pm, 1/10/22 |
| Jurickson Profar | Bridge Four | DROP | to FA | 4:49 pm, 1/10/22 |
| Wilson Ramos | Bridge Four | DROP | to FA | 4:48 pm, 1/10/22 |
| Matt Wisler | Jon Voight's Car | DROP | to FA | 2:21 pm, 10/6/21 |
| Zach Thompson | The Bluth Company | DROP | to FA | 12:31 pm, 10/2/21 |
| Corey Knebel | Chinballs | DROP | to FA | 1:24 am, 9/30/21 |
| Paolo Espino | Purple Cobras | DROP | to FA | 10:16 pm, 9/29/21 |
| Jake Woodford | Purple Cobras | DROP | to FA | 7:34 am, 9/29/21 |
| Jarlin Garcia | The Red Barons | DROP | to FA | 9:35 pm, 9/28/21 |
| Adam Ottavino | Shaolin Schmeckles | DROP | to FA | 1:28 pm, 9/28/21 |
| Yadier Molina | Purple Cobras | DROP | to FA | 8:58 am, 9/28/21 |
| Lou Trivino | Chinballs | DROP | to FA | 12:03 pm, 9/27/21 |