| Player | Team | Action | Details | |
|---|---|---|---|---|
| Wily Peralta | Chinballs | DROP | to FA | 12:03 pm, 9/27/21 |
| Andrew McCutchen | Chinballs | DROP | to FA | 12:03 pm, 9/27/21 |
| Sam Hilliard | Purple Cobras | DROP | to FA | 2:47 am, 9/27/21 |
| Sam Long | Purple Cobras | DROP | to FA | 9:25 pm, 9/26/21 |
| Andy Ibanez | Purple Cobras | DROP | to FA | 5:06 pm, 9/26/21 |
| Lewin Diaz | Purple Cobras | DROP | to FA | 1:18 am, 9/26/21 |
| J.A. Happ | Purple Cobras | DROP | to FA | 8:03 am, 9/25/21 |
| Jahmai Jones | Chinballs | DROP | to FA | 11:53 pm, 9/24/21 |
| Garrett Whitley | Chinballs | DROP | to FA | 11:46 pm, 9/24/21 |
| Robinson Cano | The Bluth Company | DROP | to FA | 2:15 pm, 9/23/21 |
| Matt Barnes | Purple Cobras | DROP | to FA | 1:58 pm, 9/23/21 |
| Omar Narvaez | The Red Barons | DROP | to FA | 1:04 pm, 9/23/21 |
| Josh Harrison | Purple Cobras | DROP | to FA | 10:05 am, 9/23/21 |
| Ryan Yarbrough | Geckos | DROP | to FA | 3:45 pm, 9/22/21 |
| Adam Oller | Purple Cobras | DROP | to FA | 2:26 pm, 9/22/21 |
| Canaan Smith | Purple Cobras | DROP | to FA | 2:26 pm, 9/22/21 |
| Logan S. Allen | Cowboys From Hell | DROP | to FA | 10:31 pm, 9/21/21 |
| Eli Morgan | The Bluth Company | DROP | to FA | 10:18 pm, 9/21/21 |
| Hector Neris | Undead Rabbits | DROP | to FA | 2:04 pm, 9/21/21 |
| Tyler Naquin | Undead Rabbits | DROP | to FA | 2:04 pm, 9/21/21 |
| Darin Ruf | Undead Rabbits | DROP | to FA | 2:03 pm, 9/21/21 |
| Terrin Vavra | Geckos | DROP | to FA | 10:38 am, 9/21/21 |
| Nick Pivetta | Chinballs | DROP | to FA | 1:26 pm, 9/20/21 |
| Harrison Bader | Chinballs | DROP | to FA | 1:26 pm, 9/20/21 |
| Justus Sheffield | The Red Barons | DROP | to FA | 10:24 am, 9/20/21 |