| Player | Team | Action | Details | |
|---|---|---|---|---|
| Elias Diaz | Purple Cobras | DROP | to FA | 12:15 pm, 9/19/21 |
| Bailey Ober | Purple Cobras | DROP | to FA | 7:28 am, 9/19/21 |
| Jon Heasley | The Bluth Company | DROP | to FA | 3:20 am, 9/19/21 |
| Paul Sewald | The Bluth Company | DROP | to FA | 3:20 am, 9/19/21 |
| Collin McHugh | The Bluth Company | DROP | to FA | 3:19 am, 9/19/21 |
| Aristides Aquino | Bullet Club | DROP | to FA | 11:46 pm, 9/18/21 |
| Edmundo Sosa | Bullet Club | DROP | to FA | 1:53 pm, 9/18/21 |
| Mike Yastrzemski | Purple Cobras | DROP | to FA | 10:59 am, 9/18/21 |
| Yasel Antuna | The Red Barons | DROP | to FA | 1:23 am, 9/18/21 |
| Vincent Velasquez | The Bluth Company | DROP | to FA | 1:25 pm, 9/17/21 |
| Tahnaj Thomas | The Red Barons | DROP | to FA | 8:51 am, 9/17/21 |
| Ken Waldichuk | The Bluth Company | DROP | to FA | 2:23 pm, 9/16/21 |
| Griffin Jax | The Bluth Company | DROP | to FA | 2:16 pm, 9/16/21 |
| Kevin Plawecki | Nixon's Nasty Ninjas | DROP | to FA | 2:00 pm, 9/16/21 |
| Janson Junk | The Bluth Company | DROP | to FA | 8:52 am, 9/16/21 |
| Jonathan Bowlan | Bullet Club | DROP | to FA | 11:52 am, 9/15/21 |
| Sam Long | Purple Cobras | DROP | to FA | 7:20 am, 9/15/21 |
| Carmen Mlodzinski | Purple Cobras | DROP | to FA | 6:30 am, 9/15/21 |
| Jake Woodford | Purple Cobras | DROP | to FA | 10:15 pm, 9/14/21 |
| Humberto Castellanos | The Bluth Company | DROP | to FA | 10:06 pm, 9/14/21 |
| Zac Lowther | The Red Barons | DROP | to FA | 12:09 pm, 9/13/21 |
| Yadier Molina | Purple Cobras | DROP | to FA | 12:58 am, 9/13/21 |
| Corey Kluber | Purple Cobras | DROP | to FA | 11:00 am, 9/12/21 |
| Eli Morgan | Purple Cobras | DROP | to FA | 5:53 pm, 9/11/21 |
| Gabriel Arias | Purple Cobras | DROP | to FA | 8:01 pm, 9/10/21 |