| Player | Team | Action | Details | |
|---|---|---|---|---|
| Julio Teheran | Scranton Yankees | DROP | to FA | 9:29 am, 5/5/21 |
| Keegan Akin | The Bluth Company | DROP | to FA | 9:28 am, 5/5/21 |
| Brandon Bielak | Purple Cobras | DROP | to FA | 4:16 am, 5/5/21 |
| Tyrone Taylor | Shaolin Schmeckles | DROP | to FA | 3:08 am, 5/5/21 |
| Ryan Zimmerman | The Bluth Company | DROP | to FA | 7:54 pm, 5/4/21 |
| Trevor Williams | Supreme Clientele | DROP | to FA | 6:01 pm, 5/4/21 |
| Michael Baumann | The Bluth Company | DROP | to FA | 3:49 pm, 5/4/21 |
| Johan Rojas | The Bluth Company | DROP | to FA | 2:05 pm, 5/4/21 |
| Clayton Beeter | The Bluth Company | DROP | to FA | 1:34 pm, 5/4/21 |
| Mauricio Dubon | The Red Barons | DROP | to FA | 12:54 pm, 5/4/21 |
| Willi Castro | The Bluth Company | DROP | to FA | 1:48 am, 5/4/21 |
| Joey Lucchesi | The Bluth Company | DROP | to FA | 12:42 am, 5/4/21 |
| Jordan Luplow | Purple Cobras | DROP | to FA | 6:29 pm, 5/3/21 |
| Will Crowe | Supreme Clientele | DROP | to FA | 6:26 pm, 5/3/21 |
| Jose De Leon | Supreme Clientele | DROP | to FA | 6:26 pm, 5/3/21 |
| Ljay Newsome | Supreme Clientele | DROP | to FA | 6:26 pm, 5/3/21 |
| Mike Fiers | Shaolin Schmeckles | DROP | to FA | 4:49 pm, 5/3/21 |
| Nick Wittgren | Ye Olde Tom Toolshed | DROP | to FA | 4:29 pm, 5/3/21 |
| Greg Holland | Ye Olde Tom Toolshed | DROP | to FA | 4:29 pm, 5/3/21 |
| Brad Miller | The Bluth Company | DROP | to FA | 12:06 pm, 5/3/21 |
| John Gant | The Red Barons | DROP | to FA | 11:08 am, 5/3/21 |
| Lucas Sims | Purple Cobras | DROP | to FA | 8:30 am, 5/3/21 |
| Bruce Zimmermann | The Bluth Company | DROP | to FA | 8:18 pm, 5/2/21 |
| Asdrubal Cabrera | Purple Cobras | DROP | to FA | 2:50 pm, 5/2/21 |
| Andrew Knizer | Purple Cobras | DROP | to FA | 9:28 am, 5/2/21 |