| Player | Team | Action | Details | |
|---|---|---|---|---|
| Mitch Moreland | Purple Cobras | DROP | to FA | 8:34 am, 5/2/21 |
| Adam Frazier | Supreme Clientele | DROP | to FA | 11:50 pm, 5/1/21 |
| Isan Diaz | The Bluth Company | DROP | to FA | 10:53 am, 5/1/21 |
| Sam Haggerty | The Bluth Company | DROP | to FA | 9:38 am, 5/1/21 |
| Jonathan Schoop | Cowboys From Hell | DROP | to FA | 8:42 am, 5/1/21 |
| Willians Astudillo | Purple Cobras | DROP | to FA | 6:53 pm, 4/30/21 |
| Alex Santos | Geckos | DROP | to FA | 3:21 pm, 4/30/21 |
| Avisail Garcia | Undead Rabbits | DROP | to FA | 12:51 pm, 4/30/21 |
| Brent Suter | Supreme Clientele | DROP | to FA | 12:00 pm, 4/30/21 |
| Genesis Cabrera | Chinballs | DROP | to FA | 11:45 am, 4/30/21 |
| Tyrone Taylor | The Red Barons | DROP | to FA | 6:26 am, 4/30/21 |
| Rafael Montero | Purple Cobras | DROP | to FA | 11:21 pm, 4/29/21 |
| Genesis Cabrera | Chinballs | DROP | to FA | 6:28 pm, 4/29/21 |
| Chris Owings | Cowboys From Hell | DROP | to FA | 7:33 am, 4/29/21 |
| Scott Barlow | Cowboys From Hell | DROP | to FA | 7:33 am, 4/29/21 |
| Mauricio Dubon | Cowboys From Hell | DROP | to FA | 7:32 am, 4/29/21 |
| J.B. Bukauskas | Purple Cobras | DROP | to FA | 11:02 pm, 4/28/21 |
| Joey Lucchesi | The Bluth Company | DROP | to FA | 12:37 pm, 4/28/21 |
| Jordan Lyles | The Bluth Company | DROP | to FA | 9:27 am, 4/28/21 |
| Andrew McCutchen | Shaolin Schmeckles | DROP | to FA | 11:10 pm, 4/27/21 |
| Wilmer Flores | Geckos | DROP | to FA | 8:10 pm, 4/27/21 |
| Corey Ray | Shaolin Schmeckles | DROP | to FA | 6:23 pm, 4/27/21 |
| Mike Fiers | Shaolin Schmeckles | DROP | to FA | 3:13 pm, 4/27/21 |
| Garrett Cooper | Chinballs | DROP | to FA | 10:42 am, 4/27/21 |
| Jordan Romero | Chinballs | DROP | to FA | 10:42 am, 4/27/21 |