| Player | Team | Action | Details | |
|---|---|---|---|---|
| Matt Adams | Scranton Yankees | DROP | to FA | 8:19 pm, 5/8/16 |
| Mike Napoli | Nixon's Nasty Ninjas | DROP | to FA | 7:30 pm, 5/8/16 |
| Miguel Andujar | The Bluth Company | DROP | to FA | 5:29 pm, 5/8/16 |
| Steve Pearce | Purple Cobras | DROP | to FA | 4:57 pm, 5/8/16 |
| Danny Santana | Purple Cobras | DROP | to FA | 4:48 pm, 5/8/16 |
| Melvin Upton Jr. | Scranton Yankees | DROP | to FA | 10:36 pm, 5/7/16 |
| Pablo Sandoval | Scranton Yankees | DROP | to FA | 10:10 pm, 5/7/16 |
| Ryan Howard | Dead Rabbits | DROP | to FA | 5:11 pm, 5/7/16 |
| Caleb Cotham | Bridge Four | DROP | to FA | 4:22 pm, 5/7/16 |
| Logan Verrett | Dead Rabbits | DROP | to FA | 1:35 pm, 5/7/16 |
| Sean Doolittle | Dead Rabbits | DROP | to FA | 1:34 pm, 5/7/16 |
| Tyler Naquin | The Red Barons | DROP | to FA | 1:05 pm, 5/7/16 |
| John Gant | Purple Cobras | DROP | to FA | 1:32 am, 5/7/16 |
| John Axford | Kimble's Kids | DROP | to FA | 10:30 pm, 5/6/16 |
| Trayce Thompson | Supreme Clientele | DROP | to FA | 9:54 pm, 5/6/16 |
| Jered Weaver | Geckos | DROP | to FA | 8:15 pm, 5/6/16 |
| Jorge Lopez | Banana Hammock | DROP | to FA | 2:24 pm, 5/6/16 |
| Chris Shaw | Jon Voight's Car | DROP | to FA | 2:07 pm, 5/6/16 |
| Edmundo Sosa | Jon Voight's Car | DROP | to FA | 1:20 pm, 5/6/16 |
| Osvaldo Abreu | Jon Voight's Car | DROP | to FA | 1:18 pm, 5/6/16 |
| Rafael Ortega | Jon Voight's Car | DROP | to FA | 12:59 pm, 5/6/16 |
| Rajai Davis | Cowboys From Hell | DROP | to FA | 12:04 pm, 5/6/16 |
| Rio Ruiz | The Bluth Company | DROP | to FA | 10:33 am, 5/6/16 |
| Tyler Cravy | Geckos | DROP | to FA | 5:28 am, 5/6/16 |
| Justin Nicolino | Chinballs | DROP | to FA | 2:34 am, 5/6/16 |